Journal
JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
Volume 12, Issue 7, Pages 5132-5137Publisher
AMER SCIENTIFIC PUBLISHERS
DOI: 10.1166/jnn.2012.6368
Keywords
Gold-Coated Iron Oxide Nanoparticles; Contrast Agent of MRI; Relaxivity
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Funding
- National Research Foundation of Korea [2010-0021315]
- Basic Science Research Program through the National Research Foundation of Korea (NRF)
- Korea government (MEST) [2009-0072413]
- Nuclear R&D Program of NRF [20090081817]
- MEST
- National Research Foundation of Korea [2009-0072413, 2010-0021315] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Gold-coated iron oxide (Fe3O4) nanoparticles were synthesized for use as a T-2 contrast agent in magnetic resonance imaging (MRI). The coated nanoparticles were spherical in shape with an average diameter of 20 nm. The gold shell was about 2 nm thick. The bonding status of the gold on the nanoparticle surfaces was checked using a Fourier transform infrared spectrometer (FTIR). The FTIR spectra confirmed the attachment of homocysteine, in the form of thiolates, to the Au shell of the Au-Fe3O4 nanoparticles. The relaxivity ratio, R-2/R-1, for the coated nanoparticles was 3-fold higher than that of a commercial contrast agent, Resovist, which showed the potential for their use as a T-2 contrast agent with high efficacy. In animal experiments, the presence of the nanoparticles in rat liver resulted in a 71% decrease in signal intensity in T-2-weighted MR images, indicating that our gold-coated iron oxide nanoparticles are suitable for use as a T-2 contrast agent in MRI.
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