Journal
JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
Volume 12, Issue 3, Pages 2081-2088Publisher
AMER SCIENTIFIC PUBLISHERS
DOI: 10.1166/jnn.2012.5743
Keywords
Biosensing; Magnetic Particles; Self-Assembly; Magnetic Colloids; Molecular Biorecognition
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Funding
- Grants-in-Aid for Scientific Research [22360139] Funding Source: KAKEN
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Superparamagnetic beads and nonmagnetic beads of different sizes were assembled to form a ring-structure in a magnetorheological (MR) fluid solution by the application of external magnetic fields. For superparamagnetic beads and non-magnetic beads functionalized with probe and target molecules, respectively, the ring-structure was maintained even after removing the external magnetic field due to biomolecular bonding. Several experiments are described, including the formation process of ring-structures with and without molecular interactions, the accelerating effect of external magnetic fields, and the effect of biotin concentration on the structures of the rings. We define the small nonmagnetic particles as petals because the whole structure looks like a flower. The number of remnant ring petals was a function of the concentration of target molecules in the concentration range of 0.0768 ng/ml similar to 3.8419 ng/ml which makes this protocol a promising method for biosensing. Not only was the formation process rapid, but the resulting two-dimensional colloidal system also offers a simple method for reducing reagent consumption and waste generation.
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