Journal
JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
Volume 11, Issue 8, Pages 6868-6874Publisher
AMER SCIENTIFIC PUBLISHERS
DOI: 10.1166/jnn.2011.4251
Keywords
Calcium Carbonate; XRD; SEM; Cytotoxicity
Categories
Funding
- NASA [NNX08BA47A, NCC-1-02038, NIH-1P20MD001822-1]
- NASA NSTI
- NSF- CREST
- Direct For Education and Human Resources
- Division Of Human Resource Development [1036494] Funding Source: National Science Foundation
- NASA [90797, NNX08BA47A] Funding Source: Federal RePORTER
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The synthesis of nanoparticles and their functionalization to effectively utilize them in biological applications including drug delivery is currently a challenge. Calcium carbonate among many other inorganic nanosized particles offers promising results for such applications. We have synthesized calcium carbonate nanoparticles using polymer mediated growth technique, where one of the ions bound within polymer matrix and the other diffuses and reacts to form desired compound. The synthesized nanoparticles are characterized using X-ray diffraction, Scanning Electron Microscopy and spectroscopic techniques such as Fourier-Transform Infra-red spectroscopy and UV-Vis spectroscopy. The diameter of the calcium carbonate nanoparticles is estimated to be 39.8 nm and their biocompatibility studies showed no significant induction of oxidative stress or cell death even. at higher concentrations (50 mu g) upon exposure to He La and LE cells. Here, we report that the synthesized calcium carbonate nanosized particles using polymer mediated growth technique are biocompatible and can be safely used for biomedical applications.
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