Journal
JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
Volume 11, Issue 2, Pages 1210-1216Publisher
AMER SCIENTIFIC PUBLISHERS
DOI: 10.1166/jnn.2011.3094
Keywords
Au Nanoparticles; In Vivo; Toxicity; Biodistribution
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Funding
- National Natural Science Foundation of China [30970733]
- National Basic Research Program of China (973 Program) [2007CB935603, 2010CB732402]
- Fujian Province University
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The toxicity and biodistribution in vivo of various morphologies of Au nanoparticles (AuNPs) were studied by using KM mice. The quantitative analysis of Au in each tissue of mice was done by using the Inductively Coupled Plasma Mass Spectrometry (ICP-MS). Sphere-shaped AuNPs displayed the best biocompatibility, compared with rod- and cube-shaped of AuNPs, and rod-shaped AuNPs was more toxic than cube-shaped AuNPs. In vivo biodistribution study revealed all AuNPs were preferentially accumulated in organ of liver and spleen. The findings from this study thus revealed that the toxicity and biodistribution in vivo of AuNPs are shape dependent.
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