Journal
JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
Volume 11, Issue 4, Pages 3100-3106Publisher
AMER SCIENTIFIC PUBLISHERS
DOI: 10.1166/jnn.2011.3758
Keywords
Nanomedicine; Carbon Nanotube; Lysozyme; Covalent Binding; Antibacterial Activity
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Funding
- Italian Ministry of Education, University and Research [RBIP06FH7J]
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We report a facile strategy to obtain multiwalled carbon nanotubes (MWCNTs) functionalized with covalently bonded lysozyme. The functionalization procedure has been investigated by means of several techniques, including thermogravimetry, Raman spectroscopy, transmission electron microscopy, and cyclic voltammetry. A functionalization of about 1 lysozyme molecule every 4000 carbon atoms is obtained. The modified lysozyme-CNTs nanocomposite shows a significant increase of the antibacterial activity towards the Gram-positive S. aureus if compared with lysozyme in solution.
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