Journal
JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
Volume 10, Issue 12, Pages 8118-8123Publisher
AMER SCIENTIFIC PUBLISHERS
DOI: 10.1166/jnn.2010.3034
Keywords
Photoacoustic Tomography; Nanobeacons; Gold Nanorod; Surface Plasmon Resonance; Near Infrared Imaging
Categories
Funding
- AHA [0835426N]
- NIH [NS059302, CA119342, HL073646, U54 CA 136398, R01EB000712, R01NS046214, EB008085]
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Molecular imaging techniques now allow recognition of early biochemical, physiological, and anatomical changes before manifestation of gross pathological changes. Photoacoustic imaging represents a novel non-ionizing detection technique that combines the advantages of optical and ultrasound imaging. Noninvasive photoacoustic tomography (PAT) imaging in combination with nanoparticle-based contrast agents show promise in improved detection and diagnosis of cardiovascular and cancer related diseases. In this report, a novel strategy is introduced to achieve self-assembled colloidal gold nanorods, which are constrained to the vasculature. Gold nanorods (2-4 nm) were incorporated into the core of self-assembled lipid-encapsulated nanoparticles (sGNR) (similar to 130 nm), providing more than hundreds of gold atoms per nanoparticle of 20% colloid suspension. The physico-chemical characterization in solution and anhydrous state with analytical techniques demonstrated that the particles were spherical and highly mono dispersed. In addition to the synthesis and characterization, sensitive near-infrared photoacoustic detection was impressively demonstrated in vitro.
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