Journal
JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
Volume 10, Issue 8, Pages 4859-4867Publisher
AMER SCIENTIFIC PUBLISHERS
DOI: 10.1166/jnn.2010.2217
Keywords
Melanoma; Quantum Dots; Polyamidoamine Dendrimer; RGD Peptide; Imaging
Categories
Funding
- China National 973 Project [200503723400-G, 2010CB933901]
- China National 863 Project [2005AA001070, 2007AA022004]
- National Natural Scientific Fund [20471599, 30672147]
- Shanghai Scientific Fund [0752nm24]
- Wenzhou Fund of Science and Technology [20070034, 07211206]
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Angiogenesis is essential for the development of malignant tumors and provides important targets for tumor diagnosis and therapy. Quantum dots have been broadly investigated for their potential application in cancer molecular imaging. In present work, CdSe quantum dots were synthesized, polyamidoamine dendrimers were used to modify surface of quantum dots and improve their solubility in water solution. Then, dendrimer-modified CdSe quantum dots were conjugated with arginine-glycine-aspartic acid (RGD) peptides. These prepared nanoprobes were injected into nude mice loaded with melanoma (A375) tumor xenografts via tail vessels, IVIS imaging system was used to image the targeting and bio-distribution of as-prepared nanoprobes. The dendrimer-modified quantum dots exhibit water-soluble, high quantum yield, and good biocompatibility. ROD-conjugated quantum dots can specifically target human umbilical vein endothelial cells (HUVEC) and A375 melanoma cells, as well as nude mice loaded with A735 melanoma cells. High-performance RGD-conjugated dendrimers modified quantum dot-based nanoprobes have great potential in application such as tumor diagnosis and therapy.
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