Journal
JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
Volume 10, Issue 8, Pages 5320-5323Publisher
AMER SCIENTIFIC PUBLISHERS
DOI: 10.1166/jnn.2010.3032
Keywords
Brain Hypoxia; Nanocarrier; EPO; Oligodendrocyte
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Funding
- National Key Program for Developing Basic Research [2007CB936104, 2010CB933903]
- Natural Science Foundation of China [60927001]
- 863 High Tech Project [2007AA021905, 2007AA022007]
- National Key Special Science Program [2009ZX10004-311]
- Scientific Research Foundation of Graduate School of Southeast University
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In this study we prepared nanocarrier of erythropoietin (EPO) and the curative effect of the EPO-containing nanoparticles for periventricular leukomalacia (PVL) model was validated. It was demonstrated that EPO-containing nanoparticles can ameliorate drug-induced liquefaction caused by hypoxia. EPO-containing nanomedicine may open new therapeutic strategies in hypoxia cure.
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