Journal
PHARMACOLOGY
Volume 96, Issue 1-2, Pages 49-54Publisher
KARGER
DOI: 10.1159/000381784
Keywords
Caudatin; UPLC-MS/MS; Rat plasma; Pharmacokinetics
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In this study, a simple, sensitive, and robust analytical method based on ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) was developed for the determination of caudatin in rat plasma using carbamazepine as internal standard (15). This method was linear over the concentration range 2.5-300 ng/ml with a lower limit of quantification (LLOQ) of 2.5 ng/ml. Inter-and intra-day precision (RSD%) were all within 10% and the accuracy (RE%) was equal or lower than 5%. Recoveries of caudatin and IS were more than 80% and matrix effects were not significant. Stability studies showed that caudatin was stable under a variety of storage conditions. The method was successfully applied to a pharmacokinetic study involving oral administration of caudatin to rats. (C) 2015 S. Karger AG, Basel
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