Journal
JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
Volume 9, Issue 2, Pages 1198-1203Publisher
AMER SCIENTIFIC PUBLISHERS
DOI: 10.1166/jnn.2009.C119
Keywords
Polyelectrolyte; Electric-Stimuli; Nanoparticle
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In the present study, the nanoparticles with size of 50-130 nm composed of chitosan (CS) and tetraethyl orthosilicate (TEOS), which showed electrically-control led release profile, were prepared. Myoglobin was encapsulated into the nanoparticles with an encapsulation efficiency as high as 91.5% and a maximum loading capacity of 70.2% that can be achieved. Here, TEOS was hydrolyzed and condensed to form interpenetration network with CS. Increase of TEOS content results in a shift of the release profile from swelling-controlled towards diffusion-controlled mechanism. The slow-to-burst and near-zero release of the myoglobin can be effectively controlled by applying DC electric field between on and off.
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