Journal
PHARMACOLOGICAL RESEARCH
Volume 92, Issue -, Pages 40-45Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phrs.2014.08.006
Keywords
Vaccine research; Modelling; Computational vaccinology; Immune system; Epitopes; Simulations
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Excepting the Peripheral and Central Nervous Systems, the Immune System is the most complex of somatic systems in higher animals. This complexity manifests itself at many levels from the molecular to that of the whole organism. Much insight into this confounding complexity can be gained through computational simulation. Such simulations range in application from epitope prediction through to the modelling of vaccination strategies. In this review, we evaluate selectively various key applications relevant to computational vaccinology: these include technique that operates at different scale that is, from molecular to organisms and even to population level. (C) 2014 Elsevier Ltd. All rights reserved.
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