Journal
JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
Volume 9, Issue 8, Pages 4586-4592Publisher
AMER SCIENTIFIC PUBLISHERS
DOI: 10.1166/jnn.2009.217
Keywords
Chitosan; Thermo-Sensitive Hydrogel; Honokiol Nanoparticles; Sustained-Release
Categories
Funding
- National High-Tech 863 Project [2007AA021902]
- National Natural Science Foundation of China [NSFC20704027]
- Sichuan Key Project of Science and Technology [2007SGY019]
- Sichuan Prominent Young Talents Program [07ZQ026-033]
- Chinese Key Basic Research Program [2004CB518807]
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In this article, a novel composite drug delivery system, honokiol nanoparticles in biodegradable hydrogels based on chitosan (CS) and beta-glycerophosphate (beta-GP), was prepared. CS/beta-GP solution was liquid at room temperature and turned into gel as temperature increased. With increase in beta-GP concentration, the sol-gel transition temperature decreased accordingly. Honokiol nanoparticles with diameter of about 30 nm were prepared by emulsion solvent evaporation method. The sol-gel transition temperature of CS/beta-GP system decreased as F-127 presented in honokiol nanoparticles. In vitro release profiles were studied, the results showed that honokiol could be slowly released from CS/beta-GP gel over at least 2 weeks and the release rate was greatly influenced by initial drug loading. The described injectable hydrogels based on chitosan (CS) and beta-glycerophosphate (beta-GP) might have potential application as local drug delivery for honokiol.
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