Journal
PHARMACOLOGICAL RESEARCH
Volume 102, Issue -, Pages 254-263Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phrs.2015.10.015
Keywords
Cannabinoid receptor; Opioid receptor; TRPV1 receptor; Receptor interaction; Pain
Categories
Funding
- National Research Development and Innovation Office (NKFIH) [OTKA 108518]
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A growing amount of data demonstrates the interactions between cannabinoid, opioid and the transient receptor potential (TRP) vanilloid type 1 (TRPV1) receptors. These interactions can be bidirectional, inhibitory or excitatory, acute or chronic in their nature, and arise both at the molecular level (structurally and functionally) and in physiological processes, such as pain modulation or perception. The interactions of these three pain-related receptors may also reserve important and new therapeutic applications for the treatment of chronic pain or inflammation. In this review, we summarize the main findings on the interactions between the cannabinoid, opioid and the TRPV1 receptor regarding to pain modulation. (C) 2015 Elsevier Ltd. All rights reserved.
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