Journal
JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
Volume 8, Issue 11, Pages 5873-5877Publisher
AMER SCIENTIFIC PUBLISHERS
DOI: 10.1166/jnn.2008.476
Keywords
Nanotechnology; Magnetic Nanoemulsion; Photodynamic Therapy; J774-A1 Cells; Zinc Phthalocyanine; Hyperthermia
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Funding
- MCT/CNPq
- FAPESP [06/50562-1, 04/00860-0]
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In this study a magnetic nanoemulsion (MNE) was developed from a mixture of two components, namely biodegradable surfactants and biocompatible citrate-coated cobalt ferrite-based magnetic fluid, for entrapment of Zn(II)-Phthalocyanine (ZnPc), the latter a classical photosensitizer (PS) species used in photodynamic therapy (PDT) procedures. The sample's stability was evaluated as a function of time using photocorrelation spectroscopy (PCS) for determination of the average hydrodynamic diameter, diameter dispersion and zeta potential. The ZnPc-loaded magneto nanoemulstion (ZnPc/MNE) formulation was evaluated in vitro assays to access the phototoxicity and the effect of application of AC magnetic fields (magnetohyperthermia damage) after incubation with J774-A1 macrophages cells. Darkness toxicity, phototoxicity and AC magnetic field exposures revealed an enhancement response for combined photodynamic and magnetohyperthermia (MHT) processes, indicating the presence of the synergic effect.
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