Journal
JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
Volume 8, Issue 6, Pages 3013-3019Publisher
AMER SCIENTIFIC PUBLISHERS
DOI: 10.1166/jnn.2008.106
Keywords
nanofibrous matrix; mineralized interface; bioactive glass; fibronectin; cell stimulation
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Exploring a material with smart and biomimetic interface has great potential in the biomaterials and tissue engineering field. This paper reports a novel nanofibrous bone matrix that was developed to retain a cell-stimulating and bone-mimetic biointerface. The bone mineral, apatite, and the cell adhesive protein, fibronectin (FN), were hybridized on the interface of a bioactive glass nanofibrous mesh, through the dissolution-and-reprecipitation process. The hybridized nanofibrous mesh showed significant improvement in the initial responses of the bone-derived cells. It is believed that this biomimetic and cell-stimulating nanofibrous mesh can be used as a potential bone regeneration matrix.
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