Journal
JOURNAL OF NANOPARTICLE RESEARCH
Volume 16, Issue 5, Pages -Publisher
SPRINGER
DOI: 10.1007/s11051-014-2407-1
Keywords
Silica; Nanoparticles; Carboranes; Polymer brushes; Non-toxic particles in biological systems
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Funding
- University of Utah Research Foundation
- National Science Foundation [DMR-1008251]
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A new class of surface-modified silica nanoparticles has been developed for potential applications in boron neutron capture therapy. Sub-50 nm silica particles were synthesized using a modified Stober method and used in surface-initiated atom transfer radical polymerization of two biocompatible polymers, poly(2-(hydroxyethyl)methacrylate) and poly(2-(methacryloyloxy)ethyl succinate). The carboxylic acid and hydroxyl functionalities of the polymeric side chains were functionalized with carboranyl clusters in high yields. The resulting particles were characterized using DLS, TEM, solution H-1 NMR, solid state B-11 NMR and thermogravimetric analysis. The particles contain between 13 and 18 % of boron atoms by weight, which would provide a high amount of B-10 nuclides for BNCT, while the polymer chains are suitable for further modification with cell targeting ligands.
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