Journal
JOURNAL OF NANOPARTICLE RESEARCH
Volume 15, Issue 1, Pages -Publisher
SPRINGER
DOI: 10.1007/s11051-012-1372-9
Keywords
Chitosan; Superparamagnetic nanoparticles; SPION; Layer-by-layer deposition; Magnetic resonance imaging; Relaxivity
Categories
Funding
- European Union from the resources of the European Regional Development Fund under the Innovative Economy Programme
- JCET-UJ [POIG.01.01.02-00-69/09]
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This article presents the synthesis and characterization of biocompatible superparamagnetic iron oxide nanoparticles (SPIONs) coated with ultrathin layer of anionic derivative of chitosan. The water-based fabrication involved a two-step procedure. In the first step, the nanoparticles were obtained by co-precipitation of ferrous and ferric aqueous salt solutions with ammonia in the presence of cationic derivative of chitosan. In the second step, such prepared materials were subjected to adsorption of oppositely charged chitosan derivative which resulted in the preparation of negatively charged SPIONs. They were found to develop highly stable dispersion in water. The core size of the nanocoated SPIONs, determined using transmission electron microscopy, was measured to be slightly above 10 nm. The coated nanoparticles form aggregates with majority of them having hydrodynamic diameter below 100 nm, asmeasured by dynamic light scattering. Their composition and properties were studied using FTIR and thermogravimetric analyses. They exhibit magnetic properties typical for superparamagnetic material with a high saturation magnetization value of 123 +/- 12 emu g(-1) Fe. Very high value of the measured r(2) relaxivity, 369 +/- 3 mM(-1) s(-1), is conducive for the potential application of the obtained SPIONs as promising contrast agents in magnetic resonance imaging.
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