Journal
JOURNAL OF NANOPARTICLE RESEARCH
Volume 14, Issue 9, Pages -Publisher
SPRINGER
DOI: 10.1007/s11051-012-1102-3
Keywords
Gold nanoparticles; Silver nanoparticles; Polymer coating; PVP; Circular dichroism; Serum albumin; Adsorption/desorption equilibrium; Protein corona
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Funding
- Deutsche Forschungsgemeinschaft (DFG) [SPP1313]
- UDE
- Centre for Water and Environmental Science (CWE)
- Bruno-Werdelmann Foundation
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When nanoparticles (NPs) come into contact with biological fluids, proteins, and other biomolecules interact with their surface. Upon exposure to biological fluids a layer of proteins adsorbs onto their surface, the so-called protein corona, and interactions of biological systems with NPs are therefore mediated by this corona. Here, interactions of serum albumin with silver and gold NPs were quantitatively investigated using circular dichroism spectroscopy. Moreover, surface enhanced Raman spectroscopy was used for further elucidation of protein binding to silver surfaces. The decisive role of poly(vinylpyrrolidone), coatings on the protein adsorption was quantitatively described for the first time and the influential role of the polymer coatings is discussed. Research in nanotoxicology may benefit from such molecular scale data as well as scientific approaches seeking to improve nanomedical applications by using a wide range of polymer surface coatings to optimize biological transport and medical action of NPs.
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