Journal
JOURNAL OF NANOPARTICLE RESEARCH
Volume 12, Issue 4, Pages 1239-1248Publisher
SPRINGER
DOI: 10.1007/s11051-009-9815-7
Keywords
Iron oxides; Contrast agents; Superparamagnetic behaviour; Bisphosphonates; NMRD profiles; Mossbauer spectrometry; Colloids; Magnetic Resonance Imaging
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Funding
- 'Collectivites territoriales' of Angers
- FNRS
- ARC of the French Community of Belgium [05/10-335]
- COST Action D38
- EMIL
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Bisphosphonates BP molecules have shown to be efficient for coating superparamagnetic iron oxide particles. In order to clarify the respective roles of electrical charge and the length of the molecules, bisphosphonates with one or two ammonium moieties with an intermediate aliphatic group of 3, 5 or 7 carbons were synthesized and iron oxide nanoparticles coated. The evaluation on their iron core properties was made by transmission electron microscopy (TEM), nuclear magnetic relaxation dispersion (NMRD) profiles and Mossbauer spectra. The core size is close to 5 nm, with a global superparamagnetic behaviour modified by a paramagnetic Fe-based layer, probably due to surface crystal alteration. The hydrodynamic sizes increase slightly with aliphatic chain length (from 9.8 to 18.6 nm). The presence of one or two ammonium group(s) lowers the negative electrophoretic mobility up to bear zero values but reduces their colloidal stability. These BP-coated iron oxide nanoparticles are promising Magnetic Resonance Imaging (MRI) contrast agents.
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