Journal
JOURNAL OF NANOMATERIALS
Volume 2010, Issue -, Pages -Publisher
HINDAWI LTD
DOI: 10.1155/2010/409320
Keywords
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Funding
- Institute of Chemical and Engineering Sciences (ICES) in Singapore
- National Science Foundation [CHE-0906179]
- Alexander von Humboldt Stiftung
- NIU
- Robert A. Welch Foundation [N-1322]
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Ortho-carborane cages have been successfully attached to modified magnetic nanoparticles via catalytic azide-alkyne cycloadditions between 1-R-2-butyl-Ortho-C2B10H10(R = Me, 3; Ph, 4) and propargyl group-enriched magnetic nanoparticles. A loading amount of 9.83 mmol boron atom/g starch-matrixed magnetic nanoparticles has been reached. The resulting nanocomposites have been found to be highly tumor-targeted vehicles under the influence of an external magnetic field (1.14T), yielding a high boron concentration of 51.4 mu g/g tumor and ratios of around 10 : 1 tumor to normal tissues.
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