Journal
PHARMACOGENOMICS
Volume 16, Issue 12, Pages 1427-1437Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/PGS.15.90
Keywords
psoriasis; responsiveness; spondyloarthropathy; TNF-alpha inhibitors; TNF-alpha polymorphism
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Funding
- Korea University
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Aim: The aim of this study is to investigate whether TNF-alpha polymorphisms are associated with the responsiveness to anti-TNF-alpha therapy in patients with spondyloarthropathy, psoriasis, and Crohn's disease. Methods: We conducted a meta-analysis on the association between the TNF-alpha polymorphisms and responsiveness of patients. Results: The meta-analysis indicated an association between the TNF-alpha -308 G allele (OR = 2.005; 95% CI: 1.417-2.838; p = 8.6 x 10-5), TNF-alpha -238 G allele (OR = 2.196; 95% CI: 1161-4.154; p = 0.016), and TNF-alpha -857 C allele (OR = 1.779; 95% CI: 1.130-2.802; p = 0.013) and response to TNF-alpha blockers in Caucasians. Conclusion: Individuals carrying the TNF-(omega) over bar -308 G, -238 G, or -857 C common alleles show better responses to TNF-alpha blockers than those with minor alleles in Caucasians.
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