Journal
PHARMACEUTICAL STATISTICS
Volume 14, Issue 5, Pages 395-399Publisher
WILEY-BLACKWELL
DOI: 10.1002/pst.1698
Keywords
pattern-mixture model; mixed-effects model repeated measures; delta variance; missing not at random
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A likelihood-based analytical approach has been proposed for the control-based pattern-mixture model and its extension. In this note, we derive equivalent but simpler analytical expressions for the treatment effect and its variance for these control-based pattern mixture models. Our formulae are easier to use and interpret. An application of our formulae to an antidepressant trial is provided, in which the likelihood-based analysis is compared with the multiple imputation approach. Copyright (C) 2015 JohnWiley & Sons, Ltd.
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