Journal
JOURNAL OF MOLECULAR STRUCTURE
Volume 1073, Issue -, Pages 24-30Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.molstruc.2014.03.066
Keywords
Bioglass; Raman spectroscopy; Collagen; Osteoblast; Hydroxyl-carbonate apatite; Bone regeneration
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This review provides a brief background on the applications, mechanisms and genetics involved with use of bioactive glass to stimulate regeneration of bone. The emphasis is on the role of structural changes of the bioactive glasses, in particular Bioglass, which result in controlled release of osteostimulative ions. The review also summarizes the use of Raman spectroscopy, referred to hereto forward as bio-Raman spectroscopy, to obtain rapid, real time in vitro analysis of human cells in contact with bioactive glasses, and the osteostimulative dissolution ions that lead to osteogenesis. The bio-Raman studies support the results obtained from in vivo studies of bioactive glasses, as well as extensive cell and molecular biology studies, and thus offers an innovative means for rapid screening of new bioactive materials while reducing the need for animal testing. (C) 2014 Elsevier B.V. All rights reserved.
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