Journal
JOURNAL OF MOLECULAR STRUCTURE
Volume 1006, Issue 1-3, Pages 77-82Publisher
ELSEVIER
DOI: 10.1016/j.molstruc.2011.05.049
Keywords
Colon adenoma and cancer; THz spectroscopy; THz imaging
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Funding
- Calouste Gulbenkian Foundation, Lisbon, Portugal
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Human normal and cancer affected samples of colon tissue have been measured using transmission time-domain terahertz spectroscopy and continuous wave terahertz imaging. We show that it is possible to distinguish between normal and cancerous regions in the samples when they a:e fixed in formalin or embedded in paraffin. The still noticeable contrast in the dried paraffin-embedded tissues could indicate that there are additional contrast-contributing factors other than water, which is the main goal of the present work. Plots of the refractive index of normal and cancer affected tissues as well as 2-D transmission THz images are shown. Experimental results are presented and the conditions for discrimination between normal and affected formalin-fixed and paraffin-embedded tissue are discussed. (C) 2011 Elsevier B.V. All rights reserved.
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