Journal
JOURNAL OF MOLECULAR STRUCTURE
Volume 936, Issue 1-3, Pages 199-205Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.molstruc.2009.07.040
Keywords
Styrylcyanine dyes; Electronic absorption and fluorescence spectra; Bovine serum albumin; Deoxyribonucleic acid; Binding
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Funding
- STCU, Ukraine [3104]
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Spectral-luminescent characteristics of the several new styrylcyanine dyes, synthesized on the base of F dye ((E)-4-(4-(dimethylamino)styryl)-1-methylpyridinium iodide), were studied in aqueous solutions in the presence and absence of bovine serum albumin and deoxyribonucleic acid. It was shown, that with the rise of concentration of bovine serum albumin and deoxyribonucleic acid in aqueous solution, the bathochromic shift of electronic absorption spectra band and sharp intensity increase of fluorescence band intensity are observed for studied dyes, while the shape of absorption and fluorescence bands remains intact. Biophysical parameters (the binding constant and quantity of the binding sites) of interaction of studied dyes with BSA and DNA were determined. It is shown, that homodimer styrylcyanine dyes with a pentyl - or longer linking chain have larger binding affinity to specified biomolecules than dyes with shorter link-chain. (C) 2009 Elsevier B. V. All rights reserved.
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