Journal
PHARMACEUTICAL CHEMISTRY JOURNAL
Volume 49, Issue 1, Pages 13-20Publisher
SPRINGER
DOI: 10.1007/s11094-015-1214-z
Keywords
phytic acid; xymedone; xymedone phytate; proton transfer reactions; antioxidant activity
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IR, UV, H-1, and C-13 NMR spectroscopic studies and potentiometric titration showed that the interaction of myoinositol hexakisphosphate (InsP(6)H(12)) and 1-(b-hydroxyethyl)-4,6-dimethyl-1,2-dihydro-2-hydroxypyrimidine (xymedone) in aqueous solution occurs via a proton transfer stage to form ionic and H-bonded complexes. In vitro study results using human plasma demonstrated synergism in antioxidant effects and activation of superoxide dismutase by phytic acid and xymedone complexed to form xymedone phytate.
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