Journal
JOURNAL OF MOLECULAR RECOGNITION
Volume 25, Issue 6, Pages 336-343Publisher
WILEY-BLACKWELL
DOI: 10.1002/jmr.2190
Keywords
molecular imprinting; hydrogel; stimuli-responsive gel; tumor marker; glycoprotein; lectin; antibody; molecular recognition
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Funding
- Ministry of Education, Culture, Sports, Science and Technology of Japan [23107532]
- Japan Society of the Promotion of Science [21300182]
- Japan Science and Technology Agency (JST)
- Grants-in-Aid for Scientific Research [24655213, 21300182] Funding Source: KAKEN
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Tumor-marker-imprinted hydrogels having lectin and antibody molecules as ligands for a tumor-specific marker glycoprotein were strategically prepared by biomolecular imprinting using minute amounts of low-molecular-weight or high-molecular-weight cross-linkers. The tumor-marker-imprinted hydrogels shrank gradually in response to a target glycoprotein, because their apparent cross-linking density increased owing to simultaneous complex formation of lectin and antibody ligands with a target glycoprotein after their ligands dynamically recognized the glycoprotein. The swelling ratio of the tumor-marker-imprinted hydrogel using high-molecular-weight cross-linker with an optimal chain length decreased more drastically than that using a low-molecular-weight cross-linker, but the hydrogel using the cross-linker with a chain that was too long did not exhibit tumor-marker responsive behavior. This paper focuses on the effect of the molecular weight of cross-linkers on the responsive behavior of tumor-marker-imprinted hydrogels having lectin and antibody molecules as ligands. The cross-linker chain length was an important factor in determining the dynamic glycoprotein recognition and responsive behavior of the biomolecule-imprinted hydrogels. Copyright (c) 2012 John Wiley & Sons, Ltd.
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