Journal
JOURNAL OF MOLECULAR NEUROSCIENCE
Volume 54, Issue 4, Pages 826-829Publisher
HUMANA PRESS INC
DOI: 10.1007/s12031-014-0427-z
Keywords
Alzheimer's disease; ATP-binding cassette subfamily B member 1 (ABCB1); P-glycoprotein (P-gp); Single nucleotide polymorphism (SNP); rs1128503 (C1236T); rs2032582 (G2677T/A); rs1045642 (C3435T)
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Funding
- [TAMOP-4.2.2A-11/1/KONV-2012-0052]
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To evaluate the association of ATP-binding cassette subfamily B member 1 (ABCB1) genetic variants with the susceptibility to Alzheimer's disease (AD), we genotyped the rs1128503 (C1236T), rs2032582 (G2677T/A), and rs1045642 (C3435T) polymorphisms in a case-control sample (234 AD patients, 225 controls). Single-marker analyses revealed a significant association solely for the rs1045642 polymorphism (C/C genotype carriers had increased risk for AD), which remains significant after correction for multiple testing. Haplotype analyses indicated three nominally significant associations which were lost after applying multiple test correction.
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