Journal
JOURNAL OF MOLECULAR NEUROSCIENCE
Volume 51, Issue 3, Pages 749-753Publisher
HUMANA PRESS INC
DOI: 10.1007/s12031-013-0058-9
Keywords
IL-17; ROR gamma t; Multiple sclerosis; Gene expression
Categories
Funding
- Tehran University of Medical Sciences (TUMS), Health Services grants, School of Nutritional Science and Dietetics
- Iranian Center for Neurological Research [10033]
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The aim of this study was to investigate the role of vitamin A on ROR gamma t and IL-17 gene expression in multiple sclerotic patients. Patients in the vitamin A group received 25,000 IU retinyl palmitate per day, while patients in the placebo group took one capsule of placebo per day for 6 months. Gene expression was measured by real-time PCR at the first and end of the study. The results of this study show that vitamin A downregulates IL-17 and ROR gamma t gene expression. No changes in gene expression occurred in the placebo group.
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