Journal
JOURNAL OF MOLECULAR NEUROSCIENCE
Volume 52, Issue 1, Pages 156-165Publisher
HUMANA PRESS INC
DOI: 10.1007/s12031-013-0190-6
Keywords
miR-124; ROCK1; Neurite elongation; PI3K/Akt
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Funding
- National Natural Science Foundation of China [81071016]
- Program for New Century Excellent Talents in University [NCET-12-0647]
- Key Project of Guangdong Province [CXZD1018]
- Program for Changjiang Scholars and the Innovative Research Team in University [IRT1142]
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Recent studies have demonstrated an important role for miR-124, the most abundant and well-conserved brain-specific microRNA(miRNA), in promoting neurite outgrowth and elongation during neuronal differentiation. This miRNA's target genes and the mechanisms that execute this role remain unclear. In this study, we identified ROCK1, a small GTPase Rho kinase, as a direct target of miR-124 for regulating neurite elongation. miR-124 significantly inhibited ROCK1 expression in M17 cells. Inhibiting ROCK1 promoted neurite elongation, and the overexpression of ROCK1 strongly repressed the neurite elongation-enhancing effect of miR-124 in M17 cells. We determined that Akt functions as a novel ROCK1 downstream effector in regulating neurite outgrowth and elongation.
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