Journal
JOURNAL OF MOLECULAR NEUROSCIENCE
Volume 51, Issue 3, Pages 687-694Publisher
HUMANA PRESS INC
DOI: 10.1007/s12031-013-0049-x
Keywords
Traumatic brain injury; FBP1; Astrocytes; Proliferation; Rats
Categories
Funding
- National Natural Science Foundation of China [81171139, 812713681]
Ask authors/readers for more resources
Far upstream element binding protein 1 (FBP1) has been identified as an upstream gene of p27(kip1) (p27), which is a key regulator of mammalian cell cycle regulation and neurogenesis. To elucidate the expression and function of FBP1 in central nervous system lesion and repair, we performed a traumatic brain injury (TBI) model in adult rats. We observed that FBP1 protein level significantly reduced at day 3 after injury, and the downregulation of FBP1 was predominant in astrocytes, which were largely proliferated after injury. Furthermore, in vitro, overexpression of FBP1 was concomitant with the up-regulation of p27 and reduction of PCNA in LPS-induced astrocyte proliferation. These results suggest that a decreased level of FBP1 in brain is involved in the proliferation of glial cells after TBI.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available