Journal
JOURNAL OF MOLECULAR NEUROSCIENCE
Volume 46, Issue 1, Pages 33-39Publisher
HUMANA PRESS INC
DOI: 10.1007/s12031-011-9562-y
Keywords
ADNP; Gene regulation; Neuroprotection; Transcription
Categories
Funding
- BBSRC
- University of Taibah, Kingdom of Saudi Arabia
- Medical Research Council [G0701003] Funding Source: researchfish
- MRC [G0701003] Funding Source: UKRI
Ask authors/readers for more resources
We investigated whether activity-dependent neuroprotective protein (ADNP) could autoregulate its own expression. Both the endogenous ADNP gene and reporter gene constructs were analysed in response to overexpression of ADNP, supplied either as wild-type ADNP or a mutant form lacking the NAP motif, a motif which has neuroprotective properties. Overexpression of these two forms of ADNP resulted in both decreased endogenous ADNP expression and repressed ADNP promoter-directed reporter gene activity. Chromatin immunoprecipitation demonstrated the ability of ADNP to bind to its own promoter which is consistent with its action as a repressor of both promoter-supported and endogenous ADNP expression.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available