Journal
JOURNAL OF MOLECULAR NEUROSCIENCE
Volume 46, Issue 3, Pages 516-526Publisher
HUMANA PRESS INC
DOI: 10.1007/s12031-011-9633-0
Keywords
Brain development; Interkinetic nuclear movement; Microcephaly
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Funding
- Israel Science Foundation [47/10, 1062/08]
- BSF [2007081]
- Minerva foundation
- Federal German Ministry for Education and Research
- ERANET-NEURON (DISCover) [IMOS 3-00000-6785]
- Benoziyo Center for Neurological diseases
- Helen and Martin Kimmel Stem Cell Research Institute
- David and Fela Shapell Family Center for Genetic Disorders Research
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The nuclei of neuroepithelial cells move along the apicobasal axis in synchronization with their cell cycle status. This motility is known as interkinetic nuclear movement. We discuss here the importance of cytoskeleton organization, the centrosome, molecular motors, cell polarity proteins, and their regulators in controlling and maintaining this typical behavior. Furthermore, due to the tight linkage between cell proliferation, cell cycle, and nuclear motility, we speculate that interkinetic nuclear movement is likely to be affected in the pathophysiology of microcephaly, where the brain size is markedly reduced.
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