Journal
JOURNAL OF MOLECULAR NEUROSCIENCE
Volume 35, Issue 1, Pages 101-116Publisher
HUMANA PRESS INC
DOI: 10.1007/s12031-007-9027-5
Keywords
connexins; gap junctions; Glia; Myelin; K+ buffering
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Funding
- NINDS NIH HHS [NS050705, K02 NS050345-04, K02 NS050345-03, R01 NS055284, R01 NS050705-04, NS054363, NS043560, NS55284, R01 NS055284-02, R01 NS043560, R01 NS050705-03, K02 NS050345, R01 NS050705, NS50345, F30 NS054363] Funding Source: Medline
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In vertebrates, a family of related proteins called connexins form gap junctions (GJs), which are intercellular channels. In the central nervous system (CNS), GJs couple oligodendrocytes and astrocytes (O/A junctions) and adjacent astrocytes (A/A junctions), but not adjacent oligodendrocytes, forming a glial syncytium. Oligodendrocytes and astrocytes each express different connexins. Mutations of these connexin genes demonstrate that the proper functioning of myelin and oligodendrocytes requires the expression of these connexins. The physiological function of O/A and A/A junctions, however, remains to be illuminated.
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