Journal
JOURNAL OF MOLECULAR MODELING
Volume 19, Issue 4, Pages 1763-1777Publisher
SPRINGER
DOI: 10.1007/s00894-012-1716-5
Keywords
Hydrogen bonding; Microsolvation of cations; Stochastic optimization
Categories
Funding
- Colciencias [CT 457-2009]
- Research Office of University of Medellin [626]
- Comite para el desarrollo de la investigacion (CODI) office, Universidad de Antioquia
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A stochastic exploration of the quantum conformational spaces in the microsolvation of divalent cations with explicit consideration of up to six solvent molecules [Mg (H (2) O) (n) )](2+), (n = 3, 4, 5, 6) at the B3LYP, MP2, CCSD(T) levels is presented. We find several cases in which the formal charge in Mg2+ causes dissociation of water molecules in the first solvation shell, leaving a hydroxide ion available to interact with the central cation, the released proton being transferred to outer solvation shells in a Grotthus type mechanism; this particular finding sheds light on the capacity of Mg2+ to promote formation of hydroxide anions, a process necessary to regulate proton transfer in enzymes with exonuclease activity. Two distinct types of hydrogen bonds, scattered over a wide range of distances (1.35-2.15 ) were identified. We find that in inner solvation shells, where hydrogen bond networks are severely disturbed, most of the interaction energies come from electrostatic and polarization+charge transfer, while in outer solvation shells the situation approximates that of pure water clusters.
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