Related references
Note: Only part of the references are listed.Hypoxic Regulation of Glutamine Metabolism through HIF1 and SIAH2 Supports Lipid Synthesis that Is Necessary for Tumor Growth
Ramon C. Sun et al.
CELL METABOLISM (2014)
XBP1 promotes triple-negative breast cancer by controlling the HIF1α pathway
Xi Chen et al.
NATURE (2014)
Genomic architecture and evolution of clear cell renal cell carcinomas defined by multiregion sequencing
Marco Gerlinger et al.
NATURE GENETICS (2014)
VHL and HIF-1α: gene variations and prognosis in early-stage clear cell renal cell carcinoma
Francesca Lessi et al.
MEDICAL ONCOLOGY (2014)
Action of hypoxia-inducible factor in liver and kidney from mice with Pax8-rtTA-based deletion of von Hippel-Lindau protein
S. Mathia et al.
ACTA PHYSIOLOGICA (2013)
Transcription Factor YY1 Contributes to Tumor Growth by Stabilizing Hypoxia Factor HIF-1α in a p53-Independent Manner
Shourong Wu et al.
CANCER RESEARCH (2013)
Activation of HIF2 alpha in Kidney Proximal Tubule Cells Causes Abnormal Glycogen Deposition but not Tumorigenesis
Leiping Fu et al.
CANCER RESEARCH (2013)
HIF expression and the role of hypoxic microenvironments within primary tumours as protective sites driving cancer stem cell renewal and metastatic progression
Beatrice Philip et al.
CARCINOGENESIS (2013)
HIF-2α Protects Human Hematopoietic Stem/Progenitors and Acute Myeloid Leukemic Cells from Apoptosis Induced by Endoplasmic Reticulum Stress
Kevin Rouault-Pierre et al.
CELL STEM CELL (2013)
The Oncogene HER2/neu (ERBB2) Requires the Hypoxia-inducible Factor HIF-1 for Mammary Tumor Growth and Anoikis Resistance
Kelly A. Whelan et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2013)
Autocrine production of IL-11 mediates tumorigenicity in hypoxic cancer cells
Barbara Onnis et al.
JOURNAL OF CLINICAL INVESTIGATION (2013)
Rho-kinase inhibition prevents the progression of diabetic nephropathy by downregulating hypoxia-inducible factor 1α
Keiichiro Matoba et al.
KIDNEY INTERNATIONAL (2013)
Comprehensivemolecular characterization of clear cell renal cell carcinoma
Chad J. Creighton et al.
NATURE (2013)
Integrated molecular analysis of clear-cell renal cell carcinoma
Yusuke Sato et al.
NATURE GENETICS (2013)
Cancer-stromal cell interactions mediated by hypoxia-inducible factors promote angiogenesis, lymphangiogenesis, and metastasis
G. L. Semenza
ONCOGENE (2013)
Prolyl hydroxylase 2 dependent and Von-Hippel-Lindau independent degradation of Hypoxia-inducible factor 1 and 2 alpha by selenium in clear cell renal cell carcinoma leads to tumor growth inhibition
Sreenivasulu Chintala et al.
BMC CANCER (2012)
VHL-Regulated MiR-204 Suppresses Tumor Growth through Inhibition of LC3B-Mediated Autophagy in Renal Clear Cell Carcinoma
Olga Mikhaylova et al.
CANCER CELL (2012)
CD31 angiogenesis and combined expression of HIF-1α and HIF-2α are prognostic in primary clear-cell renal cell carcinoma (CC-RCC), but HIFα transcriptional products are not: implications for antiangiogenic trials and HIFα biomarker studies in primary CC-RCC
Swethajit Biswas et al.
CARCINOGENESIS (2012)
The Histone Deacetylase SIRT6 Is a Tumor Suppressor that Controls Cancer Metabolism
Carlos Sebastian et al.
CELL (2012)
Searching for Hif1-α interacting proteins in renal cell carcinoma
V. Medina Villaamil et al.
CLINICAL & TRANSLATIONAL ONCOLOGY (2012)
The Acetylase/Deacetylase Couple CREB-binding Protein/Sirtuin 1 Controls Hypoxia-inducible Factor 2 Signaling
Rui Chen et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
Microtubules Regulate Hypoxia-inducible Factor-1α Protein Trafficking and Activity IMPLICATIONS FOR TAXANE THERAPY
Marisa Carbonaro et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
Hypoxia causes triglyceride accumulation by HIF-1-mediated stimulation of lipin 1 expression
Ilias Mylonis et al.
JOURNAL OF CELL SCIENCE (2012)
Comprehensive molecular portraits of human breast tumours
Daniel C. Koboldt et al.
NATURE (2012)
Complex cellular functions of the von Hippel-Lindau tumor suppressor gene: insights from model organisms
T. Hsu
ONCOGENE (2012)
ADAPTIVE AND MALADAPTIVE CARDIORESPIRATORY RESPONSES TO CONTINUOUS AND INTERMITTENT HYPOXIA MEDIATED BY HYPOXIA-INDUCIBLE FACTORS 1 AND 2
Nanduri R. Prabhakar et al.
PHYSIOLOGICAL REVIEWS (2012)
Renal Tubular HIF-2α Expression Requires VHL Inactivation and Causes Fibrosis and Cysts
Ruth E. Schietke et al.
PLOS ONE (2012)
Antiangiogenic agents increase breast cancer stem cells via the generation of tumor hypoxia
Sarah J. Conley et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
Immunoexpression Status and Prognostic Value of mTOR and Hypoxia-Induced Pathway Members in Primary and Metastatic Clear Cell Renal Cell Carcinomas
Luciana Schultz et al.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY (2011)
Targeted therapy for advanced renal cell cancer (RCC): a Cochrane systematic review of published randomised trials
Chris Coppin et al.
BJU INTERNATIONAL (2011)
High-resolution genome-wide mapping of HIF-binding sites by ChIP-seq
Johannes Schoedel et al.
BLOOD (2011)
Generation of a Mouse Model of Von Hippel-Lindau Kidney Disease Leading to Renal Cancers by Expression of a Constitutively Active Mutant of HIF1α
Leiping Fu et al.
CANCER RESEARCH (2011)
Bevacizumab Treatment for Solid Tumors Boon or Bust?
Daniel F. Hayes
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2011)
Interplay between HDAC3 and WDR5 Is Essential for Hypoxia-Induced Epithelial-Mesenchymal Transition
Min-Zu Wu et al.
MOLECULAR CELL (2011)
VEGF is essential for hypoxia-inducible factor-mediated neovascularization but dispensable for endothelial sprouting
Sunday Oladipupo et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Genetic and Functional Studies Implicate HIF1α as a 14q Kidney Cancer Suppressor Gene
Chuan Shen et al.
CANCER DISCOVERY (2011)
VHL genetic alteration in CCRCC does not determine de-regulation of HIF, CAIX, hnRNP A2/B1 and osteopontin
Michelle J. Nyhan et al.
CELLULAR ONCOLOGY (2011)
A hypoxic niche regulates glioblastoma stem cells through hypoxia inducible factor 2α
Sascha Seidel et al.
BRAIN (2010)
Silencing of HIF-1α suppresses tumorigenicity of renal cell carcinoma through induction of apoptosis
K. Xu et al.
CANCER GENE THERAPY (2010)
The Histone Deacetylase Sirt6 Regulates Glucose Homeostasis via Hif1α
Lei Zhong et al.
CELL (2010)
The Distinct Metabolic Profile of Hematopoietic Stem Cells Reflects Their Location in a Hypoxic Niche
Tugba Simsek et al.
CELL STEM CELL (2010)
Regulation of the HIF-1α Level Is Essential for Hematopoietic Stem Cells
Keiyo Takubo et al.
CELL STEM CELL (2010)
von Hippel-Lindau-Dependent Patterns of RNA Polymerase II Hydroxylation in Human Renal Clear Cell Carcinomas
Ying Yi et al.
CLINICAL CANCER RESEARCH (2010)
p21 loss blocks senescence following Apc loss and provokes tumourigenesis in the renal but not the intestinal epithelium
Alicia M. Cole et al.
EMBO MOLECULAR MEDICINE (2010)
Knock down of HIF-1α in glioma cells reduces migration in vitro and invasion in vivo and impairs their ability to form tumor spheres
Olga Mendez et al.
MOLECULAR CANCER (2010)
Reversible Epithelial to Mesenchymal Transition and Acquired Resistance to Sunitinib in Patients with Renal Cell Carcinoma: Evidence from a Xenograft Study
Hans J. Hammers et al.
MOLECULAR CANCER THERAPEUTICS (2010)
O2 regulates stem cells through Wnt/β-catenin signalling
Jolly Mazumdar et al.
NATURE CELL BIOLOGY (2010)
Inhibition of nuclear factor kappa B attenuates tumour progression in an animal model of renal cell carcinoma
Christudas Morais et al.
NEPHROLOGY DIALYSIS TRANSPLANTATION (2010)
Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics
G. L. Semenza
ONCOGENE (2010)
Effects of HIF-1 alpha and HIF2 alpha on Growth andMetabolism of Clear-Cell Renal Cell Carcinoma 786-0 Xenografts
Swethajit Biswas et al.
JOURNAL OF ONCOLOGY (2010)
Treatment of Kidney Cancer Insights Provided by the VHL Tumor-Suppressor Protein
William G. Kaelin
CANCER (2009)
Patterns of Gene Expression and Copy-Number Alterations in von-Hippel Lindau Disease-Associated and Sporadic Clear Cell Carcinoma of the Kidney
Rameen Beroukhim et al.
CANCER RESEARCH (2009)
mTOR signaling at a glance
Mathieu Laplante et al.
JOURNAL OF CELL SCIENCE (2009)
Hypoxia inducible factor-1α correlates with vascular endothelial growth factor A and C indicating worse prognosis in clear cell renal cell carcinoma
Gordana Orevic et al.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2009)
VHL loss causes spindle misorientation and chromosome instability
Claudio R. Thoma et al.
NATURE CELL BIOLOGY (2009)
Molecular mechanisms of mTOR-mediated translational control
Xiaoju Max Ma et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2009)
Hypoxia promotes expansion of the CD133-positive glioma stem cells through activation of HIF-1α
A. Soeda et al.
ONCOGENE (2009)
Regulation of cancer cell metabolism by hypoxia-inducible factor 1
Gregg L. Semenza
SEMINARS IN CANCER BIOLOGY (2009)
HIF-α Effects on c-Myc Distinguish Two Subtypes of Sporadic VHL-Deficient Clear Cell Renal Carcinoma
John D. Gordan et al.
CANCER CELL (2008)
A molecule targeting VHL-deficient renal cell carcinoma that induces autophagy
Sandra Turcotte et al.
CANCER CELL (2008)
Combination strategy targeting the hypoxia inducible factor-1 alpha with mammalian target of rapamycin and histone deacetylase inhibitors
Henk M. W. Verheul et al.
CLINICAL CANCER RESEARCH (2008)
pVHL and PTEN tumour suppressor proteins cooperatively suppress kidney cyst formation
Ian J. Frew et al.
EMBO JOURNAL (2008)
Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia
Huafeng Zhang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Efficacy of everolimus in advanced renal cell carcinoma:: a double-blind, randomised, placebo-controlled phase III trial
Robert J. Motzer et al.
LANCET (2008)
Hypoxia-inducible factor 1α in clear cell renal cell carcinoma
Tobias Klatte et al.
CLINICAL CANCER RESEARCH (2007)
Nuclear expression of hypoxia-inducible factor-1α in clear cell renal cell carcinoma is involved in tumor progression
Claudio Di Cristofano et al.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY (2007)
Hypoxia-inducible factors: central regulators of the tumor phenotype
John D. Gordan et al.
CURRENT OPINION IN GENETICS & DEVELOPMENT (2007)
Hypoxia-inducible factor lot expression in renal cell carcinoma analyzed by tissue microarray
Anders Lidgren et al.
EUROPEAN UROLOGY (2006)
Rend cyst development in mice with conditional inactivation of the von Hippel-Lindau tumor suppressor
EB Rankin et al.
CANCER RESEARCH (2006)
Contrasting properties of hypoxia-inducible factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-associated renal cell carcinoma
RR Raval et al.
MOLECULAR AND CELLULAR BIOLOGY (2005)
Retinoic acid and the histone deacetylase inhibitor trichostatin A inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model
SE Touma et al.
CLINICAL CANCER RESEARCH (2005)
Inactivation of VHL by tumorigenic mutations that disrupt dynamic coupling of the pVHL.hypoxia-inducible transcription factor-1α complex
F Miller et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Susceptibility to vascular neoplasms but no increased susceptibility to renal carcinogenesis in Vhl knockout mice
E Kleymenova et al.
CARCINOGENESIS (2004)
The eker rat: Establishing a genetic paradigm linking renal cell carcinoma and uterine leiomyoma
JD Cook et al.
CURRENT MOLECULAR MEDICINE (2004)
ONCOMINE: A cancer microarray database and integrated data-mining platform
DR Rhodes et al.
NEOPLASIA (2004)
HIF-1α mRNA and protein upregulation involves Rho GTPase expression during hypoxia in renal cell carcinoma
S Turcotte et al.
JOURNAL OF CELL SCIENCE (2003)
Inhibition of HIF2 alpha is sufficient to suppress pVHL-defective tumor growth
K Kondo et al.
PLOS BIOLOGY (2003)
Expression of hypoxia-inducible factor-1α and -2α in hypoxic and ischemic rat kidneys
C Rosenberger et al.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2002)
The contribution of VHL substrate binding and HIF1-α to the phenotype of VHL loss in renal cell carcinoma
JK Maranchie et al.
CANCER CELL (2002)
Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein
K Kondo et al.
CANCER CELL (2002)
Targeting of HIF-α to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation
P Jaakkola et al.
SCIENCE (2001)
Vascular tumors in livers with targeted inactivation of the von Hippel-Lindau tumor suppressor
VH Haase et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
Up-regulation of hypoxia-inducible factors HIF-1α and HIF-2α under normoxic conditions in renal carcinoma cells by von Hippel-Lindau tumor suppressor gene loss of function
M Krieg et al.
ONCOGENE (2000)
Share Paper
