Related references
Note: Only part of the references are listed.IDH1 Mutations in Gliomas: When an Enzyme Loses Its Grip
Christian Frezza et al.
CANCER CELL (2010)
The Common Feature of Leukemia-Associated IDH1 and IDH2 Mutations Is a Neomorphic Enzyme Activity Converting α-Ketoglutarate to 2-Hydroxyglutarate
Patrick S. Ward et al.
CANCER CELL (2010)
Leukemic IDH1 and IDH2 Mutations Result in a Hypermethylation Phenotype, Disrupt TET2 Function, and Impair Hematopoietic Differentiation
Maria E. Figueroa et al.
CANCER CELL (2010)
Expression Profiling in Progressive Stages of Fumarate-Hydratase Deficiency: The Contribution of Metabolic Changes to Tumorigenesis
Houman Ashrafian et al.
CANCER RESEARCH (2010)
The Histone Demethylase JMJD2B Is Regulated by Estrogen Receptor α and Hypoxia, and Is a Key Mediator of Estrogen Induced Growth
Jun Yang et al.
CANCER RESEARCH (2010)
Histone Methyl Transferases and Demethylases; Can They Link Metabolism and Transcription?
Raffaele Teperino et al.
CELL METABOLISM (2010)
Renal carcinoma with giant mitochondria associated with germ-line mutation and somatic loss of the succinate dehydrogenase B gene
Sarah L. Housley et al.
HISTOPATHOLOGY (2010)
The genetic and metabolic signature of oncocytic transformation implicates HIF1α destabilization
Anna Maria Porcelli et al.
HUMAN MOLECULAR GENETICS (2010)
SDHA is a tumor suppressor gene causing paraganglioma
Nelly Burnichon et al.
HUMAN MOLECULAR GENETICS (2010)
Dysregulation of hypoxia pathways in fumarate hydratase-deficient cells is independent of defective mitochondrial metabolism
Linda O'Flaherty et al.
HUMAN MOLECULAR GENETICS (2010)
IDH1 and IDH2 Gene Mutations Identify Novel Molecular Subsets Within De Novo Cytogenetically Normal Acute Myeloid Leukemia: A Cancer and Leukemia Group B Study
Guido Marcucci et al.
JOURNAL OF CLINICAL ONCOLOGY (2010)
Cancer-associated metabolite 2-hydroxyglutarate accumulates in acute myelogenous leukemia with isocitrate dehydrogenase 1 and 2 mutations
Stefan Gross et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2010)
High glucose and renin release: the role of succinate and GPR91
Janos Peti-Peterdi
KIDNEY INTERNATIONAL (2010)
SDHAF2 mutations in familial and sporadic paraganglioma and phaeochromocytoma
Jean-Pierre Bayley et al.
LANCET ONCOLOGY (2010)
Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2
Myunggon Ko et al.
NATURE (2010)
Targeting metabolic transformation for cancer therapy
Daniel A. Tennant et al.
NATURE REVIEWS CANCER (2010)
SDH5 Mutations and Familial Paraganglioma: Somewhere Warburg is Smiling
William G. Kaelin
CANCER CELL (2009)
SDHB-associated renal oncocytoma suggests a broadening of the renal phenotype in hereditary paragangliomatosis
Alex Henderson et al.
FAMILIAL CANCER (2009)
IDH1 Mutations at Residue p.R132 (IDH1R132) Occur Frequently in High-Grade Gliomas But Not in Other Solid Tumors
Fonnet E. Bleeker et al.
HUMAN MUTATION (2009)
Novel Role of Fumarate Metabolism in Dahl-Salt Sensitive Hypertension
Zhongmin Tian et al.
HYPERTENSION (2009)
The triad of paragangliomas, gastric stromal tumours and pulmonary chondromas (Carney triad), and the dyad of paragangliomas and gastric stromal sarcomas (Carney-Stratakis syndrome): molecular genetics and clinical implications
C. A. Stratakis et al.
JOURNAL OF INTERNAL MEDICINE (2009)
Fumarate Hydratase Deficiency in Renal Cancer Induces Glycolytic Addiction and Hypoxia-Inducible Transcription Factor 1α Stabilization by Glucose-Dependent Generation of Reactive Oxygen Species
Sunil Sudarshan et al.
MOLECULAR AND CELLULAR BIOLOGY (2009)
Inhibition of succinate dehydrogenase dysregulates histone modification in mammalian cells
Ana M. Cervera et al.
MOLECULAR CANCER (2009)
Cancer-associated IDH1 mutations produce 2-hydroxyglutarate
Lenny Dang et al.
NATURE (2009)
Recurring Mutations Found by Sequencing an Acute Myeloid Leukemia Genome
Elaine R. Mardis et al.
NEW ENGLAND JOURNAL OF MEDICINE (2009)
IDH1 and IDH2 Mutations in Gliomas
Hai Yan et al.
NEW ENGLAND JOURNAL OF MEDICINE (2009)
Downregulation of SRF-FOS-JUNB pathway in fumarate hydratase deficiency and in uterine leiomyomas
N. Raimundo et al.
ONCOGENE (2009)
Puzzling Patterns of Predisposition
Patrick J. Pollard et al.
SCIENCE (2009)
SDH5, a Gene Required for Flavination of Succinate Dehydrogenase, Is Mutated in Paraganglioma
Huai-Xiang Hao et al.
SCIENCE (2009)
Glioma-Derived Mutations in IDH1 Dominantly Inhibit IDH1 Catalytic Activity and Induce HIF-1α
Shimin Zhao et al.
SCIENCE (2009)
Mitochondria in cancer: Not just innocent bystanders
Christian Frezza et al.
SEMINARS IN CANCER BIOLOGY (2009)
Analysis of the IDH1 codon 132 mutation in brain tumors
Joerg Balss et al.
ACTA NEUROPATHOLOGICA (2008)
Regulation of Jumonji-domain-containing histone demethylases by hypoxia-inducible factor (HIF)-1α
Patrick J. Pollard et al.
BIOCHEMICAL JOURNAL (2008)
Cells silenced for SDHB expression display characteristic features of the tumor phenotype
Ana M. Cervera et al.
CANCER RESEARCH (2008)
The kinesin KIF1B beta acts downstream from EglN3 to induce apoptosis and is a potential 1p36 tumor suppressor
Susanne Schlisio et al.
GENES & DEVELOPMENT (2008)
The Histone Demethylases JMJD1A and JMJD2B Are Transcriptional Targets of Hypoxia-inducible Factor HIF
Sophie Beyer et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Germline SDHB mutations and familial renal cell carcinoma
Christopher Ricketts et al.
JOURNAL OF THE NATIONAL CANCER INSTITUTE (2008)
The succinate receptor GPR91 in neurons has a major role in retinal angiogenesis
Przemyslaw Sapieha et al.
NATURE MEDICINE (2008)
An integrated genomic analysis of human glioblastoma Multiforme
D. Williams Parsons et al.
SCIENCE (2008)
Loss of the SdhB, but not the SdhA subunit of complex II triggers reactive oxygen species-dependent hypoxia-inducible factor activation and tumorigenesis
Robert D. Guzy et al.
MOLECULAR AND CELLULAR BIOLOGY (2008)
Succinate inhibition of α-ketoglutarate-dependent enzymes in a yeast model of paraganglioma
Emily H. Smith et al.
HUMAN MOLECULAR GENETICS (2007)
Somatic SDHB mutation in an extraadrenal pheochromocytoma
Francien H. van Nederveen et al.
NEW ENGLAND JOURNAL OF MEDICINE (2007)
Cell-permeating α-ketoglutarate derivatives alleviate pseudohypoxia in succinate dehydrogenase-deficient cells
Elaine D. MacKenzie et al.
MOLECULAR AND CELLULAR BIOLOGY (2007)
Structural and mechanistic studies on the inhibition of the hypoxia-inducible transcription factor hydroxylases by tricarboxylic acid cycle intermediates
Kirsty S. Hewitson et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Adult Leydig cell tumors of the testis caused by germline fumarate hydratase mutations
Luis G. Carvajal-Carmona et al.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2006)
Redox stress is not essential for the pseudo-hypoxic phenotype of succinate dehydrogenase deficient cells
Mary A. Selak et al.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS (2006)
Distinct expression profile in fumarate-hydratase-deficient uterine fibroids
S Vanharanta et al.
HUMAN MOLECULAR GENETICS (2006)
Increased risk of cancer in patients with fumarate hydratase germline mutation
H. J. Lehtonen et al.
JOURNAL OF MEDICAL GENETICS (2006)
Mitochondrial tumour suppressors: A genetic and biochemical update
E Gottlieb et al.
NATURE REVIEWS CANCER (2005)
Accumulation of Krebs cycle intermediates and over-expression of HIF1α in tumours which result from germline FH and SDH mutations
PJ Pollard et al.
HUMAN MOLECULAR GENETICS (2005)
Neuronal apoptosis linked to EgIN3 prolyl hydroxylase and familial pheochromocytoma genes: Developmental culling and cancer
S Lee et al.
CANCER CELL (2005)
HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: Novel role of fumarate in regulation of HIF stability
JS Isaacs et al.
CANCER CELL (2005)
A HIF1α regulatory loop links hypoxia and mitochondrial signals in pheochromocytomas
PLM Dahia et al.
PLOS GENETICS (2005)
Mitochondrial dysfunction resulting from loss of cytochrome c impairs cellular oxygen sensing and hypoxic HIF-α activation
KD Mansfield et al.
CELL METABOLISM (2005)
Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing
RD Guzy et al.
CELL METABOLISM (2005)
Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase
MA Selak et al.
CANCER CELL (2005)
Citric acid cycle intermediates as ligands for orphan G-protein-coupled receptors
WH He et al.
NATURE (2004)
Oxygen sensing by HIF hydroxylases
CJ Schofield et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2004)
Germline mutations in FH predispose to dominantly inherited uterine fibroids, skin leiomyomata and papillary renal cell cancer
IPM Tomlinson et al.
NATURE GENETICS (2002)
The R22X mutation of the SDHD gene in hereditary paraganglioma abolishes the enzymatic activity of complex II in the mitochondrial respiratory chain and activates the hypoxia pathway
AP Gimenez-Roqueplo et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2001)
Gene mutations in the succinate dehydrogenase subunit SDHB cause susceptibility to familial pheochromocytoma and to familial paraganglioma
D Astuti et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2001)
Inherited susceptibility to uterine leiomyomas and renal cell cancer
V Launonen et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
Mutations in SDHC cause autosomal dominant paraganglioma, type 3
S Niemann et al.
NATURE GENETICS (2000)
Mutations in SDHD, a mitochondrial complex II gene, in hereditary paraganglioma
BE Baysal et al.
SCIENCE (2000)