Journal
JOURNAL OF MOLECULAR MEDICINE-JMM
Volume 89, Issue 9, Pages 833-845Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s00109-011-0767-x
Keywords
Graft-versus-host disease; Danger signals; Innate immunity; Adenosine triphosphate; Purinergic receptors; Extracellular matrix; Pathogen-associated molecular patterns; Pattern recognition receptors; Toll-like receptors; NOD-like receptors
Funding
- Deutsche Forschungsgemeinschaft, Germany [ID 7/4-2, ZE 872/1-1]
- Heisenberg Fellowship
- Deutsche Krebshilfe, Germany [ID 108977]
- [PE 1450/1-1]
Ask authors/readers for more resources
Extensive cell death with consecutive release of danger signals can cause immune-mediated tissue destruction. The abundance of cell death is likely to determine the relevance of the danger signals as physiological mechanisms that counteract immune activation may be overruled. Such constellation is conceivable in chemo-/radiotherapy-induced tissue damage, reperfusion injury, trauma, and severe infection. Studies on graft-versus-host disease (GvHD) development have to consider the effects of chemo-/radiotherapy-related tissue damage leading to the release of exogenous and endogenous danger signals. Our previous work has demonstrated a role for adenosine-5'-triphosphate (ATP) as an endogenous danger signal in GvHD. Besides ATP, uric acid or soluble extracellular matrix components are functional danger signals that activate the NLRP3 inflammasome when released from dying cells or from extracellular matrix. In contrast to sterile inflammation, GvHD is more complex since bacterial components that leak through damaged intestinal barriers and the skin can activate pattern recognition receptors and directly contribute to GvHD pathogenesis. These exogenous danger signals transmit immune activation via toll-like receptors and NOD-like receptors of the innate immune system. This review covers both the impact of endogenous and exogenous danger signals activating innate immunity in GvHD.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available