Journal
JOURNAL OF MOLECULAR MEDICINE-JMM
Volume 88, Issue 9, Pages 873-880Publisher
SPRINGER
DOI: 10.1007/s00109-010-0638-x
Keywords
Dendritic cells; Toll-like receptors; CD14; Innate immunity; Apoptosis
Funding
- European Union [DC-THERA: LSHG-CT-2004-512074, TOLERAGE: HEALTHF-4-2008-202156, ENCITE: HEALTH-F4-2008-201842]
- Associazione Italiana per la Ricerca sul Cancro (AIRC)
- Italian Ministry of Education and Research (COFIN)
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Dendritic cells (DCs) sense the presence of pathogens through germline-encoded pattern recognition receptors (PRRs), which recognize molecular patterns expressed by various microorganisms and endogenous stimuli. Toll-like receptors (TLRs) are the best characterized PRRs. TLR activation has a profound effect on a number of DC activities, including endocytosis, cytoskeleton rearrangement, migration, antigen processing and presentation, survival, and death. The goal of TLR-induced DC reprogramming is to promote the appropriate activation and differentiation of lymphocytes bearing clonally distributed antigen-specific receptors. In this review, we will focus on the functional consequences of TLR engagement for conventional DCs.
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