Journal
JOURNAL OF MOLECULAR MEDICINE-JMM
Volume 87, Issue 7, Pages 663-668Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s00109-009-0459-y
Keywords
Endocannabinoids; Leptin action; Adipose tissue; Mediobasal hypothalamus; Fat metabolism
Funding
- National Institutes of Health [DK074873]
- European Foundation for the Study of Diabetes
- American Diabetes Association
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Endocannabinoids (ECs) are small lipid mediators that play a critical role in energy metabolism. Human studies have shown that the EC tone in peripheral tissues positively correlates with increased adiposity. Furthermore, pharmacological inhibition of EC signaling results in weight loss in humans. However, the mechanisms that cause the dysregulation of the EC system in obesity are not well-understood. Since the clinical utility of currently available EC blockers is severely limited due to their side effects like depression and suicidal ideation that are caused by central effects, it is important to delineate the role of central and peripheral effects of EC signaling in regulating glucose and lipid metabolism.
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