Journal
JOURNAL OF MOLECULAR MEDICINE-JMM
Volume 86, Issue 6, Pages 679-684Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s00109-008-0325-3
Keywords
angiotensin-converting enzyme; mice; gene targeting; tissue-specific expression; heart; macrophages
Funding
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [K99HL088000] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R01DK051445, R01DK039777] Funding Source: NIH RePORTER
- NHLBI NIH HHS [K99 HL088000, K99 HL 088000] Funding Source: Medline
- NIDDK NIH HHS [R01 DK 051445, R01 DK 039777, R01 DK039777, R01 DK051445] Funding Source: Medline
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Angiotensin-converting enzyme (ACE) has been well-recognized for its role in blood pressure regulation. ACE is made by many tissues, though it is most abundantly expressed on the luminal surface of vascular endothelium. ACE knockout mice show a profound phenotype with low blood pressure, but also with hemopoietic and developmental defects, which complicates understanding the biological functions of ACE in individual tissue types. Using a promoter-swapping strategy, several mouse lines with unique ACE tissue expression patterns were studied. These include mice with ACE expression in the liver (ACE 3/3), the heart (ACE 8/8), and macrophages (ACE 10/10). We also investigated mice with a selective inactivation of either the N- or C-terminal ACE catalytic domain. Our studies indicate that ACE plays a role in many other physiologic processes beyond simple blood pressure control.
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