Journal
JOURNAL OF MOLECULAR LIQUIDS
Volume 195, Issue -, Pages 188-193Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.molliq.2014.02.016
Keywords
Conjugate addition; alpha,beta-Unsaturated ketones; Choline chloride-urea; Ultrasonication; Ionic liquid catalyst
Funding
- UGC-CAS
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A green protocol for efficient synthesis of beta-functionalized ketonic derivatives is achieved with the combination of ultrasound and the deep eutectic solvent (DES) choline chloride-urea [ChCl:urea (1:2)]. Under optimized conditions, nucleophilic attack of active methylene on alpha,beta-unsaturated ketones gives the conjugate addition product in the short span of 40-50 min an excellent yield of 89-95%. The experimental procedure is very simple, easy to set up, solvent free and completely eliminates the use of any toxic metal catalyst. The use of ChCl:urea as a biodegradable, recyclable and reusable catalyst (up to five cycles) further increases the scope of the developed methodology. (C) 2014 Elsevier B.V. All rights reserved.
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