Journal
JOURNAL OF MOLECULAR LIQUIDS
Volume 180, Issue -, Pages 34-38Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.molliq.2012.12.028
Keywords
Piroxicam; Ethanol; Binary mixtures; Extended Hildebrand Solubility Approach; Solubility parameter
Ask authors/readers for more resources
In this work the Extended Hildebrand Solubility Approach (EHSA) was applied to evaluate the solubility of the analgesic drug piroxicam in some ethanol + water mixtures at 298.15 K. Experimental solubility and some properties of fusion of this drug were used. An acceptable correlative capacity of EHSA was found using a regular polynomial model in order five (overall deviation 2.41%), when the W interaction parameter is related to the solubility parameter of the co-solvent mixtures. Nevertheless, the overall deviation obtained by using EHSA was the same as the one obtained directly by means of an empiric regression of the logarithmic experimental solubility as a function of the mixture solubility parameter. (C) 2013 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available