Journal
JOURNAL OF MOLECULAR LIQUIDS
Volume 156, Issue 1, Pages 28-32Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.molliq.2010.05.017
Keywords
Hydrogels; Chondroitin Sulphate release device; Mathematical models; Diffusion; Partition phenomenon
Funding
- CNPq (Brazil)
- CAPES (Brazil)
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Hydrogels based on complexes of Chitosan/Chondroitin Sulphate (CT/CS) can be formed just by mixing and have been applied as devices for CS releasing. In the CT/CS complex investigated in this work, the release of CS occurs mainly at pHs higher than 6.5, the value of pKa(CT), and the maximum fraction of CS released is close to 0.5. In this work, the release of CS was treated as a diffusional transport process and as a partition phenomenon in which a partitioning of solutes between the solvent phase and the hydrogel phase occurs. Mathematical models for predicting the in vitro CS release profile from CT/CS polymer network were used. The hydrogel showed to be pH-responsive and values of half-time for CS releasing are compatibles for the application of CT/CS hydrogels in pharmacological field as devices for CS controlled release. (C) 2010 Elsevier B.V. All rights reserved.
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