Journal
JOURNAL OF MOLECULAR GRAPHICS & MODELLING
Volume 40, Issue -, Pages 116-124Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jmgm.2012.12.009
Keywords
Acridone; AHPRRR; 3D-QSAR; Pharmacophore; Docking; Calmodulin
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Funding
- SERB, Department of Science and Technology (DST), Government of India [SR/FT/LS-175/2009]
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Calmodulin inhibitors have proved to play a significant role in sensitizing MDR cancer cells by interfering with cellular drug accumulation. The present investigation focuses on the evaluation of in vitro inhibitory efficacy of chloro acridones against calmodulin dependent cAMP phosphodiesterase (PDE1c). Moreover, molecular docking of acridones was performed with PDE1c in order to identify the possible protein ligand interactions and results thus obtained were compared with in vitro data. In addition an efficient pharmacophore model was developed from a set of 38 chemosensitizing acridones effective against doxorubicin resistant (HL-60/DX) cancer cell lines. Pharmacophoric features such as one hydrogen bond acceptor, one hydrophobic region, a positive ion group and three aromatic rings i.e., AHPRRR have been identified. Ligand based 3D-QSAR was also performed by employing partial least square regression analysis. (C) 2013 Elsevier Inc. All rights reserved.
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