Journal
JOURNAL OF MOLECULAR EVOLUTION
Volume 66, Issue 6, Pages 591-597Publisher
SPRINGER
DOI: 10.1007/s00239-008-9110-8
Keywords
gene duplication; caspase-1 inhibitors
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Caspase 1 (CASP-1) inhibitors share sequence similarity to CASP-1 itself and are all mapped to chr11q22.3. Here we show that these inhibitors are all products of a series of gene duplications that occurred at this locus after the divergence between human and mouse. Surprisingly, stop codons originated independently in all duplicated copies to generate CARD-only proteins with inhibitory activity. We discuss this evolutionary model in the context of both neo- and subfunctionalization.
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