Journal
JOURNAL OF MOLECULAR ENDOCRINOLOGY
Volume 50, Issue 2, Pages R21-R37Publisher
BIOSCIENTIFICA LTD
DOI: 10.1530/JME-12-0247
Keywords
polycystic ovary syndrome; adipokines; obesity; adipose tissue
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Funding
- National Natural Science Foundation of China [81100398, 81270943]
- Research Fund for the Doctoral Program of Higher Education [20100001120036]
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Polycystic ovary syndrome (PCOS) is the most common endocrinopathy associated with infertility and metabolic disorder in women of reproductive age. Dysfunction of adipose tissue has been implicated in the pathophysiology of PCOS. Increasing evidence shows that the dysregulated expression of adipokines, the secreted products of adipose tissue, plays an important role in the pathology of PCOS. Here, we review the role of several identified adipokines that may act as a link between obesity and PCOS. PCOS also reciprocally influences the profile of adipokines. Insight into the underlying mechanisms will help better understand the pathology of PCOS and identify new therapeutic targets of this syndrome.
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