Journal
JOURNAL OF MOLECULAR ENDOCRINOLOGY
Volume 50, Issue 1, Pages R11-R19Publisher
BIOSCIENTIFICA LTD
DOI: 10.1530/JME-12-0203
Keywords
Apoptosis; Cardiovascular; Diabetes (all); Signal transduction
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Funding
- Glenn Foundation
- National Institute of Health [1R01AG 034430, 1R01GM 090311, 1R01ES 020812, 1R21DK 089447]
- Ellison Medical Foundation/AFAR fellowship
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The discovery of humanin, a novel, mitochondrial-derived peptide, has created a potentially new category of biologically active peptide. As more research unravels the endogenous role of humanin as well as its potential pharmacological use, its role in stress resistance has become clearer. Humanin protects cells from oxidative stress, serum starvation, hypoxia, and other insults in vitro and also improves cardiovascular disease as well as Alzheimer's disease in vivo. In this review, we discuss the emerging role of humanin in stress resistance and its proposed mechanism of action.
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