Journal
JOURNAL OF MOLECULAR ENDOCRINOLOGY
Volume 46, Issue 1, Pages R1-R9Publisher
BIOSCIENTIFICA LTD
DOI: 10.1677/JME-10-0122
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Funding
- Ministerio de Ciencia e Innovacion, Spain [BFU2008-02950-C03-01/02]
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Selective estrogen receptor modulators (SERMs), used for the treatment of breast cancer, osteoporosis, and menopausal symptoms, affect the nervous system. Some SERMs trigger neuroprotective mechanisms and reduce neural damage in different experimental models of neural trauma, brain inflammation, neurodegenerative diseases, cognitive impairment, and affective disorders. New SERMs with specific actions on neurons and glial cells may represent promising therapeutic tools for the brain.
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