Journal
JOURNAL OF MOLECULAR ENDOCRINOLOGY
Volume 44, Issue 3, Pages 143-154Publisher
BIOSCIENTIFICA LTD
DOI: 10.1677/JME-09-0107
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Funding
- Center for Cancer Research, National Cancer Institute, National Institutes of Health
- NATIONAL CANCER INSTITUTE [ZIABC008752, ZIABC011191] Funding Source: NIH RePORTER
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Peroxisome proliferator-activated receptors (PPARs) and thyroid hormone receptors (TRs) are members of the nuclear receptor superfamily. They are ligand-dependent transcription factors that interact with their cognate hormone response elements in the promoters to regulate respective target gene expression to modulate cellular functions. While the transcription activity of each is regulated by their respective ligands, recent studies indicate that via multiple mechanisms PPARs and TRs crosstalk to affect diverse biological functions. Here, we review recent advances in the understanding of the molecular mechanisms and biological impact of crosstalk between these two important nuclear receptors, focusing on their roles in adipogenesis and carcinogenesis.
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